The research objective of this paper is to examine the role of bionic design in advancing sustainable development within industrial design by outlining its theoretical framework; analyzing its applications in morphological, functional, and material aspects; identifying current challenges; and projecting future trends toward eco-integration, resourc
PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma
Identifying cancer drivers and actionable mutations is critical for precision oncology.In epithelial ovarian cancer (EOC) the majority of mutations lack biological or clinical validation.We fully characterized 43 lines of Patient-Derived Xenografts (PDXs) and performed copy number analysis and whole exome sequencing of 12 lines derived from naï
Activity of Nitric Oxide Is Dependent On, But Is Partially Required for Function of, Salicylic Acid in the Signaling Pathway in Tobacco Systemic Acquired Resistance
When tobacco plants were treated by injection with nitric oxide (NO)-releasing compounds, the sizes of lesions caused by Tobacco mosaic virus (TMV) on the treated leaves and on upper nontreated leaves were significantly reduced.The reduction in TMV lesion size was caused by NO released from the NO-releasing compounds; the byproduct formed after rel
Insights into the Pathogenesis and Development of Recombinant Japanese Encephalitis Virus Genotype 3 as a Vaccine
Japanese encephalitis virus (JEV), a flavivirus transmitted by mosquitoes, has caused epidemics and severe neurological diseases in Asian countries.In this study, we developed a cDNA infectious clone, pBAC JYJEV3, of the JEV genotype 3 strain (EF571853.1) using a bacterial artificial chromosome (BAC) vector.The constructed infectious clone was tran
Novel uterine lavage system for recovery of human embryos fertilized and matured in vivo
Alexander Nadal,1 Sam Najmabadi,2,3 Bruce Addis,1 John E Buster1,41Department of Research and Development, Previvo Genetics, San Carlos, CA 94070, USA; 2Division of Reproductive Endocrinology and Infertility, Punta Mita Hospital, Punta Mita, Nayarit 63734, Mexico; 3Division of Reproductive Endocrinology and Infertility, Center for Reproductive Heal